| Matrix Gla protein | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MGP; MGLAP; NTI | ||||||||||||
| External IDs | OMIM: 154870 MGI: 96976 HomoloGene: 693 GeneCards: MGP Gene | ||||||||||||
|
|||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4256 | 17313 | |||||||||||
| Ensembl | ENSG00000111341 | ENSMUSG00000030218 | |||||||||||
| UniProt | P08493 | P19788 | |||||||||||
| RefSeq (mRNA) | NM_000900.3 | NM_008597.3 | |||||||||||
| RefSeq (protein) | NP_000891.2 | NP_032623.1 | |||||||||||
| Location (UCSC) | Chr 12: 15.03 – 15.04 Mb |
Chr 6: 136.82 – 136.82 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Matrix gla protein (MGP) is a protein found in numerous body tissues that requires vitamin K for its optimum function. It is present in bone (together with the related vitamin K-dependent protein osteocalcin), as well as in heart, kidney and lung. In bone, its production is increased by vitamin D.
Contents |
The MGP was linked to the short arm of chromosome 12 in 1990.[1]
MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires Vitamin K hydroquinone. This process also occurs with a number of proteins involved in coagulation: prothrombin, factor VII, factor IX and factor X, protein C, protein S and protein Z.
Abnormalities in the MGP gene have been linked with Keutel syndrome, a rare condition characterised by abnormal calcium deposition in cartilage, peripheral stenosis of the pulmonary artery, and midfacial hypoplasia.[2]
Mice that lack MGP develop to term but die within two months as a result of arterial calcification which leads to blood-vessel rupture.[3]
|
||||||||||||||||||||||||||||||